Calabar AB announced
that their Phase II repeated dose study in xerostomia ("dry mouth")
patients has been initiated. Specifically, the drug will be studied in 45
dry mouth patients between the ages of 20 to 75. The objective of the study
is to select a dose for evaluation in a succeeding Phase III efficacy
study.
Xalieve(TM) is a gel containing the cholinesterase inhibitor
physostigmine. It is administered locally in the mouth where physostigmine
diffuses through the mucosa reaching the minor glands. By inhibiting
cholinesterase, acetylcholine accumulates and the elevated concentrations
stimulate the muscarinic receptors in the minor glands, improving saliva
production. Unlike systemically administered drugs, the local route of
administration limits adverse events.
"Xalieve(TM) offers a completely new approach in treating dry mouth and
we are very excited about this Phase II study," said Mr. Fredrik Rook, VP
Business Development of Calabar. "Xerostomia is not getting the attention
it deserves. These patients are experiencing dramatic decrease in quality
of life, such as difficulty in swallowing and speaking, and a burning
sensation in the mouth. Xalieve(TM) has the possibility to radically
improve the life of millions of people suffering from dry mouth."
About Calabar AB:
Calabar is a privately-held company committed to developing
pharmaceutical products addressing the significant unmet needs of
xerostomia "dry mouth". The company's product Xalieve(TM) is a locally
administered formulation of the cholinesterase inhibitor physostigmine,
which has been shown to effectively increase salivary flow. The company is
part of the Karolinska Development AB portfolio. For more information,
please visit calabar.se
Calabar AB
calabar.se