Boston Scientific Corporation (NYSE: BSX) welcomed an article in the February 19 issue of the Journal of American College of Cardiology (JACC),1 which reported the TAXUS™ paclitaxel-eluting coronary stent system, when used in diabetic patients, lowered the need for repeat procedures by 50 percent versus bare-metal stents while maintaining numerically lower but not significantly different rates of heart attack and death. The relative safety and efficacy advantage of TAXUS Stents over bare-metal stents (BMS) in diabetic patients extended to both those requiring and not requiring insulin and was sustained and durable over a period of four years.

The TAXUS™ Libert?©™ Stent received European CE Mark approval for use in patients with diabetes2 in December 2007 and is to date the only drug-eluting stent specifically indicated for use in diabetics in the European Economic Area.

The pooled analysis included five prospective, double-blind, randomised trials comprising a total of 3,513 patients treated with the TAXUS Stent and BMS of which 827 were diabetics. At four-year follow-up, there were no significant differences between the TAXUS Stent and BMS among diabetic patients in the rates of death (8.4% vs. 10.3%, respectively, p=0.61), myocardial infarction (6.9% vs. 8.9%, p=0.17), or stent thrombosis (1.4% vs. 1.2%, p=0.92, per protocol). The use of the TAXUS Stent compared with BMS was associated with a significant and durable reduction in target lesion revascularisation over the four-year follow-up period (12.4% vs. 24.7%, p Boston Scientific is a worldwide developer, manufacturer and marketer of medical devices whose products are used in a broad range of interventional medical specialties. For more information, please visit: bostonscientific-international.

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This press release contains forward-looking statements within the meaning of Section 21E of the Securities Exchange Act of 1934. Forward-looking statements may be identified by words like "anticipate," "expect," "project," "believe," "plan," "estimate," "intend" and similar words. These forward- looking statements are based on our beliefs, assumptions and estimates using information available to us at the time and are not intended to be guarantees of future events or performance. These forward-looking statements include, among other things, statements regarding our product performance, regulatory approval of our products, competitive offerings, our growth strategy, and our market position. If our underlying assumptions turn out to be incorrect, or if certain risks or uncertainties materialize, actual results could vary materially from the expectations and projections expressed or implied by our forward-looking statements. These factors, in some cases, have affected and in the future (together with other factors) could affect our ability to implement our business strategy and may cause actual results to differ materially from those contemplated by the statements expressed in this press release. As a result, readers are cautioned not to place undue reliance on any of our forward-looking statements.

Factors that may cause such differences include, among other things: future economic, competitive, reimbursement and regulatory conditions; new product introductions; demographic trends; intellectual property; litigation; financial market conditions; and, future business decisions made by us and our competitors. All of these factors are difficult or impossible to predict accurately and many of them are beyond our control. For a further list and description of these and other important risks and uncertainties that may affect our future operations, see Part I, Item 1A - Risk Factors in our most recent Annual Report on Form 10-K filed with the Securities and Exchange Commission, which we may update in Part II, Item 1A - Risk Factors in Quarterly Reports on Form 10-Q we have filed or will file thereafter. We disclaim any intention or obligation to publicly update or revise any forward- looking statements to reflect any change in our expectations or in events, conditions, or circumstances on which those expectations may be based, or that may affect the likelihood that actual results will differ from those contained in the forward-looking statements. This cautionary statement is applicable to all forward-looking statements contained in this document.

References

1. Kirtane AJ, Ellis SG, Dawkins KD, et al. Paclitaxel-eluting coronary stents in patients with diabetes mellitus: pooled analysis from 5 randomized trials. J Am Coll Cardiol 2008;51(7):708-15.

2. Indicated for patients with concomitant diabetes mellitus.

3. Wild S, Roglic G, Green A, et al. Global prevalence of diabetes: estimates for the year 2000 and projections for 2030. Diabetes Care 2004;27(5):1047-53.

4. Bartnik M, Ryden L, Ferrari R, et al. The prevalence of abnormal glucose regulation in patients with coronary artery disease across Europe. The Euro Heart Survey on diabetes and the heart. Eur Heart J 2004;25(21):1880-90.

5. Ryden L, Standl E, Bartnik M, et al. Guidelines on diabetes, pre-diabetes, and cardiovascular diseases: executive summary. The Task Force on Diabetes and Cardiovascular Diseases of the European Society of Cardiology (ESC) and of the European Association for the Study of Diabetes (EASD). Eur Heart J 2007;28(1):88-136.

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